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Shire Human Genetic Therapies

Pharmaceutical Preparations, Cambridge, Massachusetts. NPDES permit MA0040321 expired Mar 31, 2026; its limits still apply. Last 12 months: no values over a limit, 3 of 14 reports late. Source: EPA ECHO, Oct 22, 2026.

Reports due: About 15 days after each period: form A monthly (7 values), form Q quarterly (4 values)
Last report on file: August 2026
Oct 2024 – Sep 2025: 0 values over a limit, 0 required values missing, 1 of 16 reports late

Limits in force (11)

Parameter	Statistic	Limit	Months
Flow rate	monthly average	≤ 20000 gal/d	all year
Flow rate	daily maximum	≤ 30000 gal/d	all year
Oxygen, dissolved [DO]	minimum	≥ 5 mg/L	all year
pH	minimum	≥ 6.5 SU	all year
pH	maximum	≤ 8.3 SU	all year
Solids, total suspended	monthly average	≤ 30 mg/L	all year
Solids, total suspended	daily maximum	≤ 45 mg/L	all year
Copper, total [as Cu]	monthly average	≤ 52 ug/L	all year
Copper, total [as Cu]	daily maximum	≤ 73 ug/L	all year
Chlorine, total residual	monthly average	≤ .22 mg/L	all year
Chlorine, total residual	daily maximum	≤ .27 mg/L	all year

How strict are these limits?

Solids, total suspended, daily maximum 45 mg/L — stricter than 70% of 27 other minor industrial and other permits in Massachusetts; 4% have the same limit
pH, maximum 8.3 SU — stricter than 46% of 45 other minor industrial and other permits in Massachusetts; 49% have the same limit
Chlorine, total residual, monthly average .22 mg/L — stricter than 41% of 2,336 other minor industrial and other permits nationwide

Cited limits by parameter: Massachusetts's rules and the federal ones.

Same industry: the 4 Chemicals and Allied Products permits in Massachusetts.

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On EPA ECHO: Facility report · DMR history

Your permit document is the final word. As JSON: /api/v1/permits/MA0040321 · MCP: https://passage-data.com/mcp